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Monocyte adherence to human vascular endothelium
1Department of Infectious Diseases, University Hospital, Leiden, The Netherlands.
Journal of Leukocyte Biology
|October 1, 1993
Summary
Monocytes adhere to and migrate across blood vessel walls during inflammation. This review details the molecular mechanisms and adhesion molecules involved in monocyte extravasation, crucial for inflammatory responses.
Area of Science:
- Immunology
- Cell Biology
- Vascular Biology
Background:
- Acute inflammation necessitates monocyte recruitment to inflamed tissues.
- Monocyte migration across the endothelium is a critical step in inflammatory responses.
- Cytokines and chemoattractants regulate monocyte margination and extravasation.
Purpose of the Study:
- To review the mechanisms of monocyte adhesion to endothelial cells.
- To summarize the process of monocyte transendothelial migration.
- To highlight the role of adhesion molecules in monocyte-endothelial cell interactions.
Main Methods:
- Literature review of studies on monocyte-endothelial cell interactions.
- Analysis of the contribution of specific adhesion molecule families.
- Detailed discussion of the sequential events in monocyte extravasation.
Main Results:
- Monocyte adhesion and transendothelial migration are sequential events.
- Beta 1- and beta 2-integrins, immunoglobulin superfamily members, and selectins mediate these interactions.
- The review details the step-by-step process of monocytes crossing the endothelium.
Conclusions:
- Understanding monocyte-endothelial cell interactions is key to controlling inflammation.
- Adhesion molecules play a pivotal role in regulating monocyte recruitment.
- This review consolidates current knowledge on monocyte extravasation mechanisms.