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Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
08:56

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Published on: February 10, 2015

Bleeding as presenting symptom of cholestasis

J N van den Anker1, M Sinaasappel

  • 1Department of Pediatrics, Erasmus University, Rotterdam, The Netherlands.

Journal of Perinatology : Official Journal of the California Perinatal Association
|July 1, 1993
PubMed

Four infants with conjugated hyperbilirubinemia who were brought for treatment primarily because of a hemorrhage are reported. Underlying disorders included extrahepatic biliary atresia, choledochal cysts, and alpha 1-antitrypsin deficiency. Prodromal signs of disturbed coagulation and diminished bile excretion were not recognized. The increased bleeding tendency was probably caused by vitamin K deficiency, resulting from a combination of cholestasis-induced fat malabsorption, absence of vitamin K supplementation after birth, and low vitamin K intake as a result of breast feeding.

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