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Recent advances in molecular and genetic analysis of Rh blood group structures
Y Colin1, B Cherif-Zahar, C Le Van Kim
1Unité INSERM U76, Institut National de Transfusion Sanguine, Paris, France.
Journal of Medical Primatology
|January 1, 1993
Abstract:
The Rh antigens are carried by 30-32 kDa integral proteins of the red cell membrane. The Rh locus is composed of two genes: RhD, which encodes the major D antigen and is present only in Rh-positive genomes, and RhCcEe, which encodes both the Cc and Ee polypeptides, most likely by alternative splicing events. The D and non-D Rh mRNAs have been cloned. Their sequence homology suggest that the two Rh genes have evolved by duplication of a common ancestor.