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Intravitreal large-cell lymphoma
1Department of Ophthalmology, Mayo Clinic Rochester, MN 55905.
Mayo Clinic Proceedings
|October 1, 1993
Summary
Ocular large-cell lymphoma, a type of non-Hodgkin's lymphoma, can affect the eye and mimic inflammatory conditions. Early diagnosis via vitreous biopsy and combined treatments have improved patient prognosis.
Area of Science:
- Ophthalmology
- Hematology
- Oncology
Background:
- Large-cell lymphoma can infiltrate ocular tissues, including the vitreous, uveal tract, retina, and optic nerve.
- Ocular lymphoma often presents bilaterally (80% of cases) and may precede central nervous system involvement.
- This condition typically affects individuals around 60 years old, with a higher prevalence in women.
Purpose of the Study:
- To describe the clinical presentation, diagnosis, and management of ocular large-cell lymphoma.
- To highlight the potential for ocular lymphoma to mimic other eye conditions.
- To discuss recent advances in treatment and their impact on prognosis.
Main Methods:
- Cytologic and immunocytochemical analysis of vitreous biopsy specimens obtained via aspiration or pars plana vitrectomy.
- Review of clinical data including patient demographics, ocular and systemic involvement, and treatment outcomes.
Main Results:
- Ocular large-cell lymphoma can present as vitreous cellular infiltrates, mimicking uveitis or infectious diseases.
- Diagnosis relies on specialized examination of vitreous samples.
- Combined therapy involving irradiation, corticosteroids, and chemotherapy has led to improved outcomes.
Conclusions:
- Ocular large-cell lymphoma requires a high index of suspicion due to its potential to mimic other ocular conditions.
- Prompt diagnosis through vitreous biopsy is crucial for effective management.
- Multimodal treatment strategies have significantly improved the prognosis for patients with ocular large-cell lymphoma.
