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Aging and the human pituitary gland
T Sano1, K T Kovacs, B W Scheithauer
1Department of Pathology, University of Tokushima School of Medicine, Japan.
Mayo Clinic Proceedings
|October 1, 1993
Summary
Aging pituitary glands show increased fibrosis, particularly in men, with a decrease in somatotrophs. Other age-related changes like amyloid deposits and squamous metaplasia were observed.
Area of Science:
- Endocrinology
- Gerontology
- Pathology
Background:
- The pituitary gland undergoes age-related changes that can affect its function.
- Understanding these alterations is crucial for comprehending aging processes and associated health conditions.
Purpose of the Study:
- To investigate histological and immunohistochemical age-related alterations in the human pituitary gland.
- To compare changes in aged individuals with younger control groups.
Main Methods:
- Autopsy-obtained pituitary glands from elderly individuals (90-98 years) and younger controls (30-89 years) were analyzed.
- Histological and immunohistochemical techniques were employed to assess tissue changes.
Main Results:
- Significant interstitial and perivascular fibrosis was observed in 88% of aged pituitary glands, more pronounced in men.
- A decrease in somatotrophs was noted in proportion to fibrosis extent.
- Amyloid and iron deposits, squamous metaplasia, and basophil invasion were also detected.
Conclusions:
- Aging significantly impacts the pituitary gland, characterized by increased fibrosis and altered cell populations.
- These findings contribute to the understanding of pituitary gland aging and its potential functional consequences.