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Related Experiment Videos

Asthma deaths in children--a continuing problem

C M Mellis, P D Phelan

    Thorax
    |February 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Five children with severe asthma died, highlighting risks of inhaled corticosteroids and the need for oral steroids during exacerbations. This underscores the importance of careful management in high-risk pediatric asthma patients.

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    Area of Science:

    • Pediatric Pulmonology
    • Clinical Pathology
    • Pharmacology

    Background:

    • Asthma management in children often involves long-term corticosteroid therapy.
    • Inhaled corticosteroids are frequently used for maintenance therapy in severe pediatric asthma.
    • Monitoring for systemic side effects of corticosteroid treatment is crucial.

    Observation:

    • Five pediatric asthma fatalities were analyzed over a 12-month period.
    • All deceased children had severe, chronic asthma requiring maintenance corticosteroid therapy.
    • Three children received beclomethasone dipropionate via inhalation and showed acute tracheobronchial inflammation.

    Findings:

    • Histological examination revealed adrenal atrophy in four cases, despite normal short tetracosactrin tests.

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  • Acute inflammation of the tracheobronchial tree was noted in children using inhaled beclomethasone dipropionate.
  • These cases suggest potential systemic effects and insufficient management of exacerbations.

    • Implications:

    • High-dose oral corticosteroids are essential for managing asthma exacerbations in children previously treated with oral steroids.
    • The use of inhaled beclomethasone dipropionate may be associated with an increased risk in certain pediatric asthma populations.
    • Further research is needed to optimize corticosteroid regimens and minimize adverse events in severe pediatric asthma.