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Erythromycin-antacid interaction

M S Arayne1, N Sultana

  • 1Department of Chemistry, Faculty of Pharmacy, University of Karachi, Pakistan.

Die Pharmazie
|August 1, 1993
PubMed
Summary
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The study found that most antacids significantly slow down erythromycin stearate release in vitro. Only sodium hydrogen carbonate did not affect the drug

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery
  • Pharmacokinetics

Background:

  • Erythromycin stearate is a common antibiotic.
  • Antacids are frequently co-administered with medications.
  • Interactions between antacids and antibiotics can affect drug efficacy.

Purpose of the Study:

  • To investigate the in vitro effect of various antacids on erythromycin stearate release.
  • To determine if antacids alter the dissolution profile of erythromycin stearate.
  • To explore the potential mechanisms behind any observed interactions.

Main Methods:

  • Utilized the United States Pharmacopeia (USP) XX dissolution method for in vitro testing.
  • Studied the release of erythromycin stearate in the presence of specific antacids: aluminium hydroxide, aluminium trisilicate, magnesium oxide, magnesium trisilicate, sodium hydrogen carbonate, and a combination formulation.

Related Experiment Videos

  • Compared dissolution rates with and without antacid presence.

    • Main Results:

    • A marked retardation in erythromycin stearate dissolution was observed with most tested antacids.
    • Aluminium hydroxide, aluminium trisilicate, magnesium oxide, magnesium trisilicate, and the combination formulation significantly inhibited drug release.
    • Sodium hydrogen carbonate was the only antacid that did not show a retarding effect on erythromycin stearate dissolution.

    Conclusions:

    • Co-administration of erythromycin stearate with common antacids (excluding sodium hydrogen carbonate) can significantly impede its in vitro drug release.
    • The observed retarding effect suggests potential alterations in drug absorption or efficacy when erythromycin stearate is taken with these antacids.
    • Further investigation into the specific mechanisms of interaction is warranted to understand clinical implications.