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Updated: Aug 6, 2026
10:09
Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence
Published on: January 7, 2019
Biological actions of oncogenes
M R Smith1, N T Matthews, K A Jones
1Biological Carcinogenesis and Development Program, Program Resources Inc., DynCorp, National Cancer Institute, Frederick Cancer Research and Development Center, MD 21702.
Pharmacology & Therapeutics
|January 1, 1993
Summary
Cancer arises from multistep genetic mutations, often involving proto-oncogenes and tumor suppressor genes. Understanding their normal functions versus their roles in oncogenic transformation is key to cancer research.
Area of Science:
- Molecular Biology
- Genetics
- Cancer Research
Background:
- Cancer develops through accumulated genetic mutations.
- Specific genes are susceptible to mutations due to chromosomal location or cell cycle control roles.
- Dysregulation of growth/differentiation pathways or cell cycle inhibitors activates oncogenesis.
Purpose of the Study:
- To compare the normal functions of proto-oncogenes with the transforming activities of oncogenes.
- To explore the roles of tumor suppressor genes in cancer development.
- To discuss potential mechanisms driving oncogenic transformation.
Main Methods:
- Review of existing literature on oncogenes and tumor suppressor genes.
- Comparative analysis of gene functions in normal versus cancerous cells.
- Discussion of molecular mechanisms underlying oncogenic transformation.
Main Results:
- Proto-oncogenes regulate normal cell growth and differentiation.
- Oncogenes result from mutated proto-oncogenes, promoting uncontrolled cell proliferation.
- Tumor suppressor genes normally inhibit cell growth; their inactivation contributes to cancer.
Conclusions:
- Understanding oncogenes and tumor suppressor genes is crucial for deciphering cancer's molecular origins.
- Mechanisms of oncogenic transformation involve the interplay between these gene types.
- Further research into these genetic factors can inform cancer prevention and treatment.
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02:18Cancer
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01:33Cancer-Critical Genes I: Proto-oncogenes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:33Cancer-Critical Genes I: Proto-oncogenes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
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