Rhythms in the immune system

This report reviews the evidence that cells within the immune system are subject to rhythmic influences that affect numbers of circulating cells and their function both in vitro and in vivo. It is concluded that, although periodicity has clearly been demonstrated for numbers of immunocompetent cells in the circulation, significant functional changes have not been consistently observed. A number of neuroendocrine hormones, which modulate immune responsiveness in vitro and which are released in a rhythmic manner, are considered as mediators of the observed effects on the immune system and this is related to changes in expression and activity of immune-mediated diseases such as rheumatoid arthritis.