Effects of light stimulation on the activity of the autonomic nerves in anesthetized rats

The existence of the retino-hypothalamic pathway suggests that light stimulation may influence the activity of the autonomic outflows. Efferent activities of the pancreatic, hepatic, and gastric branches of the vagus nerve and those of pancreatic, hepatic, splenic, adrenal, and renal branch of the splanchnic nerve were recorded. Light stimulation with 2000 1x for 10 min to the left eye increased the splanchnic (sympathetic) outflows and suppressed the vagal outflows. The effects lasted for several hours. The minimal effective stimulation was 20 1x for 1 min or 200 1x for 0.1 min. These responses were observed in the light period as well as dark period. However, in the suprachiasmatic nucleus (SCN) lesioned rat, the changes in autonomic outflows following light stimulation were absent. The observations suggest that light stimulation modulates visceral functions through changes in the autonomic nervous system activities via the SCN.