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Related Experiment Videos

Functional mapping of the rat brain during drinking behavior: a fluorodeoxyglucose study

F Gonzalez-Lima1, F J Helmstetter, J Agudo

  • 1Department of Psychology, University of Texas, Austin 78712.

Physiology & Behavior
|September 1, 1993
PubMed
Summary

This study mapped brain activity during drinking using [14C]2-fluoro-2-deoxy-D-glucose (FDG). It revealed key areas like the lateral hypothalamus and limbic structures involved in reward and arousal during motivated drinking behavior.

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Area of Science:

  • Neuroscience
  • Behavioral Neuroscience
  • Neuroimaging

Background:

  • Understanding the neural circuits underlying motivated behaviors like drinking is crucial.
  • Previous studies have explored aspects of drinking, but a comprehensive functional map is lacking.

Purpose of the Study:

  • To map the functional activity in the central nervous system (CNS) during motivated drinking behavior.
  • To identify specific brain structures involved in the rewarding and arousal components of drinking.

Main Methods:

  • Autoradiographic techniques utilizing the radiolabeled glucose analog [14C]2-fluoro-2-deoxy-D-glucose (FDG).
  • Rats were trained to drink, with FDG injected during drinking or after satiation to compare metabolic activity.
  • FDG uptake was quantified across 60 brain structures from the frontal cortex to the cervical spinal cord.

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Main Results:

  • The lateral hypothalamus showed the largest increase in activity (96%) during drinking.
  • Significant metabolic increases were observed in limbic structures (lateral septum, lateral habenula, nucleus accumbens) and thalamic nuclei.
  • Activated areas included the caudal caudate nucleus and spinal trigeminal nucleus, suggesting sensorimotor involvement.

Conclusions:

  • The study provides the first comprehensive functional map of brain systems involved in drinking behavior.
  • Findings highlight the role of reward and arousal systems in motivated drinking.
  • Sensorimotor aspects of orofacial stimulation during drinking are also implicated.