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Drugs acting on the intracellular signalling system
Y Nomura1, Y Kitamura, M Tohda
1Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Medicinal Research Reviews
|January 1, 1993
Summary
Cellular signaling pathways are crucial for cell life and are targets for new drugs. This review details signaling factors and therapeutic drugs acting on them for clinical use.
Area of Science:
- Cellular biology
- Molecular pharmacology
- Drug discovery
Background:
- Cellular response to extracellular signals is fundamental for cell survival.
- Signaling molecules are key targets for therapeutic drug development.
- Recent advances have revealed molecular properties of intracellular signaling factors.
Purpose of the Study:
- To summarize the properties of various signaling factors.
- To identify novel drugs targeting these signaling molecules.
- To provide a comprehensive overview for clinical application.
Main Methods:
- Literature review of cellular signaling pathways.
- Analysis of molecular properties (subtypes, structures, functions) of signaling factors.
- Compilation of drugs acting on signaling molecules.
Main Results:
- Detailed properties of key signaling factors including receptors, ion channels, GTP binding proteins, enzymes, and protein kinases/phosphatases are presented.
- Novel drugs with new mechanisms of action targeting these signaling molecules have been identified.
- Tables A-H list drugs with potential clinical applications.
Conclusions:
- Understanding cellular signaling is vital for developing targeted therapies.
- Numerous drugs targeting signaling molecules show promise for clinical use.
- This review serves as a resource for researchers and clinicians in pharmacology and cell biology.