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[123I]HIPDM pulmonary imaging demonstrates elastase-induced pulmonary emphysema
W J Shih1, Y L Lai, J J Coupal
1Nuclear Medicine Service, Department of Veterans Affairs Medical Center, Lexington, KY 40511.
Lung
|January 1, 1993
Summary
[123I]hydroxyiodobenzyl-propanediamine (HIPDM) imaging shows reduced uptake in emphysematous rat lungs. This suggests HIPDM may be a useful diagnostic tool for detecting pulmonary emphysema.
Area of Science:
- Nuclear medicine
- Radiopharmaceutical imaging
- Pulmonary diagnostics
Background:
- [123I]hydroxyiodobenzyl-propanediamine (HIPDM) shows high lung localization after intravenous injection.
- Pulmonary emphysema is a lung disease characterized by damage to air sacs.
Purpose of the Study:
- To evaluate the potential of [123I]HIPDM as a lung imaging agent for detecting pulmonary emphysema.
- To compare [123I]HIPDM imaging with [99mTc]MAA lung perfusion imaging in an animal model.
Main Methods:
- Pulmonary emphysema was induced in Long-Evans rats using intratracheal elastase.
- Treated and nontreated rats were imaged using [99mTc]MAA and [123I]HIPDM via scintillation camera.
- Lung activity was measured, normalized by lung volume, and ratios of treated/nontreated rats were computed.
Main Results:
- A significant decrease in uptake of both [123I]HIPDM (p < 0.021) and [99mTc]MAA (p < 0.025) was observed in elastase-treated lungs.
- These decreases indicate reduced functioning vascular endothelium and fewer pulmonary capillaries.
- Imaging results correlated with increased mean linear intercept in treated lungs (p < 0.005).
Conclusions:
- [123I]HIPDM uptake reduction in emphysematous lungs reflects damage to pulmonary capillaries and arterioles.
- [123I]HIPDM imaging may serve as an alternative diagnostic method for pulmonary emphysema.
- The imaging modality reflects pulmonary endothelial receptor function.