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Bronchial hyperresponsiveness in children with atopic dermatitis

S P Salob1, A Laverty, D J Atherton

  • 1Department of Dermatology, Hospitals for Sick Children, London, England.

Pediatrics
|January 1, 1993
PubMed
Summary

Children with atopic dermatitis often show bronchial hyperresponsiveness, a condition affecting airways. This heightened airway sensitivity is present even in those without diagnosed asthma, indicating a significant link.

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Area of Science:

  • Pediatric Allergy and Immunology
  • Dermatology
  • Pulmonology

Background:

  • Atopic dermatitis is a common allergic skin condition in children.
  • Bronchial hyperresponsiveness is a key feature of asthma.
  • The relationship between atopic dermatitis and airway hyperresponsiveness requires further investigation.

Purpose of the Study:

  • To assess bronchial hyperresponsiveness in children with atopic dermatitis.
  • To compare airway responsiveness in children with atopic dermatitis and asthma versus those with atopic dermatitis alone.
  • To investigate the association between atopic dermatitis and bronchial hyperresponsiveness in the absence of asthma symptoms.

Main Methods:

  • Histamine provocation tests were used to measure bronchial responsiveness.

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  • Participants included children aged 7-15 years with atopic dermatitis.
  • Groups comprised children with diagnosed asthma and those without asthma symptoms, plus a control group.

    • Main Results:

    • All but one child with atopic dermatitis and asthma exhibited bronchial hyperresponsiveness.
    • A significant majority (18/22) of children with atopic dermatitis alone also showed bronchial hyperresponsiveness.
    • Bronchial hyperresponsiveness was significantly more severe in asthmatic subjects compared to non-asthmatic subjects with atopic dermatitis.

    Conclusions:

    • Atopic dermatitis is strongly associated with bronchial hyperresponsiveness in children.
    • Bronchial hyperresponsiveness can be present in children with atopic dermatitis even without a history of asthma.
    • Findings suggest a shared underlying mechanism or predisposition linking atopic dermatitis and airway hyperreactivity.