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Immunoglobulin A in split ejaculates of patients with prostatitis
Urology
|February 1, 1977
Summary
In chronic prostatitis, immunoglobulin A (IgA) levels in seminal fluid may increase due to elevated 7S and 11S IgA, primarily originating from the prostate gland.
Area of Science:
- Urology
- Immunology
Background:
- Chronic prostatitis is a common condition affecting men.
- Immunoglobulin A (IgA) plays a role in mucosal immunity.
- Understanding IgA's role in prostatitis is crucial for diagnosis and treatment.
Purpose of the Study:
- To investigate the levels and origin of different forms of immunoglobulin A (IgA) in patients with chronic prostatitis.
Main Methods:
- Studied split ejaculates from 17 chronic prostatitis patients and 16 healthy controls.
- Utilized the Hanson radial immunogel filtration method to quantify 7S and 11S IgA.
Main Results:
- Elevated levels of both 7S and 11S IgA were observed in certain prostatitis cases.
- The primary source of increased IgA in these cases appears to be the prostate gland.
Conclusions:
- Increased seminal IgA in some prostatitis patients involves both 7S and 11S forms.
- Prostatic origin of elevated IgA suggests local immune response in chronic prostatitis.