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Free protein S deficiency in acute ischemic stroke. A case-control study
S A Mayer1, R L Sacco, A Hurlet-Jensen
1Department of Neurology, Columbia-Presbyterian Medical Center, New York.
Stroke
|February 1, 1993
Summary
Acquired free protein S deficiency is common in hospitalized patients but not a significant risk factor for ischemic stroke in older adults. This study investigated the association between free protein S levels and stroke risk.
Area of Science:
- Hematology
- Neurology
- Vascular Medicine
Background:
- Free protein S is a natural anticoagulant.
- Acquired deficiency can occur during acute illness.
- It's increasingly recognized as a potential stroke risk factor.
Purpose of the Study:
- To determine if free protein S deficiency is linked to acute cerebral infarction in older, stroke-risk individuals.
Main Methods:
- Measured free protein S using Laurell rocket immunoelectrophoresis.
- Compared 94 adults with acute cerebral infarction to 94 age/sex/race-matched controls.
- Excluded controls with predisposing conditions for deficiency.
Main Results:
- Free protein S deficiency (<20% normal) was similar in cases (21%) and controls (20%).
- Deficiency was more prevalent in Black individuals (34%) vs. non-Blacks (13%).
- Very low free protein S (<15% normal) was more frequent in cases but not statistically significant.
Conclusions:
- Acquired free protein S deficiency is common in hospitalized patients, even without known causes.
- The study indicates it's not a major risk factor for ischemic stroke.