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Manic syndrome early and late in the course of HIV

C G Lyketsos1, A L Hanson, M Fishman

  • 1Department of Psychiatry and Behavioral Sciences, Johns Hopkins University and Hospital, Baltimore, MD.

The American Journal of Psychiatry
|February 1, 1993
PubMed

Insights

Manic syndromes impact 8% of patients with Acquired Immunodeficiency Syndrome (AIDS). Those without a prior mood disorder history experienced later HIV progression and more dementia.

Area of Science:

  • Neuropsychiatry
  • Infectious Diseases
  • HIV/AIDS Research

Background:

  • Acquired Immunodeficiency Syndrome (AIDS) can manifest with various neuropsychiatric complications.
  • Understanding the prevalence and characteristics of manic syndromes in AIDS patients is crucial for comprehensive care.

Purpose of the Study:

  • To determine the prevalence of manic syndromes in patients with AIDS.
  • To investigate the clinical features and associations of manic episodes in this population.

Main Methods:

  • Retrospective chart review conducted at a hospital's infectious disease AIDS clinic.
  • Analysis of patient demographics, medical history, and clinical presentation of manic episodes.

Main Results:

  • Manic syndromes were observed in 8% of the reviewed AIDS patient cohort.
  • Among 14 patients with manic episodes, those lacking a personal or family history of mood disorders presented later in their HIV infection.
  • This subgroup also exhibited a higher incidence of comorbid dementia.

Conclusions:

  • Manic syndromes represent a significant neuropsychiatric complication in patients with AIDS.
  • The absence of a prior mood disorder history may indicate a distinct pathway for manic syndrome development in advanced HIV infection, often associated with cognitive decline.

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