Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease of glomerular hyperfiltration in short-term diabetic adolescents without microalbuminuria

E Bognetti1, F Meschi, R Bonfanti

  • 1Scientific Institute H San Raffaele, Milano, Italy.

Diabetes Care
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Loss of NUMB drives aggressive bladder cancer via a RHOA/ROCK/YAP signaling axis.

Nature communications·2024
Same author

Case report: A case of Rabson-Mendenhall syndrome: long-term follow-up and therapeutic management with empagliflozin.

Frontiers in genetics·2024
Same author

CDK12 promotes tumorigenesis but induces vulnerability to therapies inhibiting folate one-carbon metabolism in breast cancer.

Nature communications·2022
Same author

<sup>68</sup>Ga-DOTATOC PET/MR imaging and radiomic parameters in predicting histopathological prognostic factors in patients with pancreatic neuroendocrine well-differentiated tumours.

European journal of nuclear medicine and molecular imaging·2022
Same author

Radiomics in pancreatic neuroendocrine tumors: methodological issues and clinical significance.

European journal of nuclear medicine and molecular imaging·2021
Same author

Pancreatic metastases from primary ileal NET only detected by 68Ga-DOTATOC PET/CT.

European journal of nuclear medicine and molecular imaging·2020
Same journal

A Secular Increase in the Incidence of Islet Autoimmunity Among Colorado Children With Moderate-Risk HLA Genotypes.

Diabetes care·2026
Same journal

Clinical and Biochemical Recovery From Immune Checkpoint Inhibitor-Induced Diabetes With Seroconversion of GAD Antibodies.

Diabetes care·2026
Same journal

State Insulin Out-of-Pocket Cap Policies and Estimated Eligible Populations in the United States, 2019-2026.

Diabetes care·2026
Same journal

Genetic Determinants of Macronutrient Intake Are Associated With Specific Food Intake in Youth: A Cohort Study Across Childhood and Adolescence.

Diabetes care·2026
Same journal

A Novel Electronic Medical Record Search Method to Identify Patients With Ketosis-Prone Diabetes: Implications for Discovery of Atypical Diabetes.

Diabetes care·2026
Same journal

Real-Time Continuous Glucose Monitoring Among People With Type 2 Diabetes and End-Stage Kidney Failure Undergoing Maintenance Hemodialysis: A Randomized Clinical Trial.

Diabetes care·2026
See all related articles

Young patients with insulin-dependent diabetes mellitus (IDDM) and hyperfiltration show a faster decline in glomerular filtration rate (GFR) over three years, without increased microalbuminuria compared to those with normal GFR.

Area of Science:

  • Nephrology
  • Endocrinology
  • Pediatrics

Background:

  • Diabetic kidney disease is a major complication of diabetes mellitus.
  • Early detection and monitoring of kidney function in young patients with diabetes are crucial.
  • Glomerular hyperfiltration is an early sign of diabetic kidney disease.

Purpose of the Study:

  • To prospectively investigate the changes in glomerular filtration rate (GFR) and urinary albumin excretion (UAE) in young patients with short-term insulin-dependent diabetes mellitus (IDDM).
  • To compare the progression of kidney function in patients with initial glomerular hyperfiltration versus those with normal GFR.

Main Methods:

  • Prospective study of 19 patients with glomerular hyperfiltration and 19 with normal GFR, matched for age and diabetes duration.

Related Experiment Videos

  • GFR assessed by radioisotopic tracer and UAE by radioimmunoassay (RIA) at baseline and after approximately 30 months.
  • Analysis of GFR decline, UAE, blood pressure (BP), and microalbuminuria prevalence at follow-up.

    • Main Results:

    • GFR decreased in both groups, but the decline was significantly greater in the hyperfiltration group (0.83 vs. 0.28 ml/min/month; P < 0.01).
    • No significant differences in UAE, BP, or microalbuminuria prevalence were observed between groups at follow-up.
    • The rate of GFR decline correlated positively with initial GFR (r = 0.59, P < 0.001).

    Conclusions:

    • Glomerular hyperfiltration in young IDDM patients is associated with a more pronounced decline in GFR over a 3-year period.
    • This accelerated GFR decline does not appear to be linked to an increased rate of microalbuminuria in this cohort.
    • These findings highlight the importance of monitoring kidney function in young diabetics, particularly those with hyperfiltration.