The effect of intraarterial administered aminophylline on cerebral hemodynamics in man

The dose-effect relationship of intracarotid administered aminophylline on cerebral hemodynamics in man was investigated by means of an intraarterial 133Xenon injection method. A dose dependent vasoconstriction was clearly demonstrated. The maximum efficacy expressed as measured decreased in global cerebral blood flow was 21.9 per cent +/- 6.2 SD. Administration of as little as 1 mg aminophylline produced a measureable vasoconstriction.