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Primary actinomycoma of the third ventricle--the colloid cyst. A histochemical and ultrastructural study
Abstract:
Primary actinomycoma of the third ventricle has been reported to be a very rare form of central nervous system actinomycosis. Others have demonstrated actinomycotic-like colonies in colloid cysts of the third ventricle. We have confirmed these structures (HLS) in five colloid cysts and have demonstrated by various histochemical stains that they consist of desoxyribose nucleic acid, base protein and phospholipid. Ultrastructurally, they consist of amorphous to granular electron dense material, probably deposited on a lamellar substructure. On the basis of the available information, we believe that the lesions, previously reported as primary actinomycomas, are actually colloid cysts containing degenerative HLS. The possible origin of the hyphal-like structures is discussed.
Insights
Central nervous system actinomycosis, specifically primary actinomycoma of the third ventricle, is rare. This study identifies hyphal-like structures (HLS) in colloid cysts, suggesting these are the actual cause of previously reported actinomycomas.
Area of Science:
- Neuropathology
- Microbiology
- Histology
Background:
- Primary actinomycoma of the third ventricle is an exceptionally rare central nervous system (CNS) actinomycosis.
- Previous studies have suggested the presence of actinomycotic-like colonies within colloid cysts of the third ventricle.
Observation:
- Hyphal-like structures (HLS) were identified in five colloid cysts of the third ventricle.
- Histochemical staining revealed HLS composed of desoxyribose nucleic acid, base protein, and phospholipid.
- Ultrastructural analysis showed HLS as amorphous to granular electron-dense material on a lamellar substructure.
Findings:
- The study confirms the presence of HLS within colloid cysts.
- The composition of HLS was elucidated through histochemical and ultrastructural methods.
- Degenerative HLS within colloid cysts are proposed as the explanation for previously reported primary actinomycomas of the third ventricle.
Implications:
- Reclassifies previously identified primary actinomycomas of the third ventricle as colloid cysts containing HLS.
- Provides insight into the nature and composition of HLS found in CNS lesions.
- Suggests a need to re-evaluate diagnostic criteria for CNS actinomycosis, particularly in the third ventricle.