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Local reflex in microcirculation in human skeletal muscle

O Henriksen, P Sejrsen

    Acta Physiologica Scandinavica
    |January 1, 1977
    PubMed
    Summary

    Venous stasis reduces human skeletal muscle blood flow via a local sympathetic axon reflex. This reflex, independent of the central nervous system, significantly impacts vascular conductance changes.

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    Area of Science:

    • Physiology
    • Vascular Biology
    • Neuroscience

    Background:

    • Venous stasis can affect blood flow regulation.
    • The role of local reflexes in skeletal muscle vascular control is not fully understood.

    Purpose of the Study:

    • To investigate the effect of venous stasis on human skeletal muscle blood flow.
    • To elucidate the underlying mechanisms of vasoconstriction during venous stasis.

    Main Methods:

    • Measured skeletal muscle blood flow using the 133Xenon washout technique.
    • Utilized venous stasis (40 mmHg) and histamine-induced passive vascular beds.
    • Administered spinal sympathetic blockade, lidocaine, and phentolamine.
    • Compared responses in normal subjects and sympathectomized patients.

    Main Results:

    • Venous stasis (40 mmHg) decreased skeletal muscle blood flow by approximately 30%.
    • Histamine-induced vasodilation showed a smaller decrease (16%), suggesting a vasoconstrictor response to increased transmural pressure.
    • The vasoconstrictor response was blocked by local anesthetics and adrenergic blockers but unaffected by spinal blockade.
    • The response was absent in sympathectomized patients' denervated limbs.

    Conclusions:

    • Skeletal muscle vasoconstriction during venous stasis is mediated by a local nervous mechanism involving adrenergic fibers.
    • A sympathetic axon reflex, similar to that in cutaneous tissue, appears to operate in human skeletal muscle.
    • This local reflex contributes significantly to vascular conductance changes, independent of central nervous system control.

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