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Updated: Aug 8, 2026

Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling
Published on: August 3, 2018
Transforming growth factor beta exerts opposite effects from interleukin-1 beta on cultured rabbit articular
F Rédini1, A Mauviel, S Pronost
1Laboratoire de Biochimie du Tissu Conjonctif, CHU Côte de Nacre, Caen, France.
Objective:
The aim of the study was to determine whether transforming growth factor beta (TGF beta) modulates the effects and the receptor expression of interleukin-1 (IL-1) in rabbit articular chondrocytes (RAC).
Methods:
Collagen, glycosaminoglycan, and collagenase production, together with 125I-labeled IL-1 binding, were analyzed in RAC cultures.
Results:
TGF beta reduced both IL-1 effects on matrix metabolism and IL-1 receptor expression.
Conclusion:
TGF beta acts as an antagonist of the effects of IL-1 through down-regulation of its receptor expression.
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