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A simple and effective treatment for hemorrhagic radiation proctitis using formalin
F Seow-Choen1, H S Goh, K W Eu
1Department of Colorectal Surgery, Singapore General Hospital.
Diseases of the Colon and Rectum
|February 1, 1993
Summary
Endoluminal formalin effectively treats radiation proctitis, a severe rectal bleeding complication. This simple therapy offers a safe and inexpensive solution for patients unresponsive to other treatments.
Area of Science:
- Gastroenterology
- Oncology
- Radiation Oncology
Background:
- Radiation proctitis is a frequent complication following pelvic radiotherapy.
- Severe cases involve intractable hemorrhage, necessitating frequent hospitalizations and transfusions.
- Existing medical treatments are often ineffective, and surgery carries significant risks.
Purpose of the Study:
- To evaluate the efficacy of endoluminal formalin therapy for hemorrhagic radiation proctitis.
- To assess the safety and simplicity of this treatment modality.
Main Methods:
- Eight patients with radiation-induced rectal bleeding underwent endoluminal formalin application with minimal contact technique.
- Patients had a median age of 68 and a history of cervical or prostate cancer treated with radiotherapy.
- The median duration of bleeding symptoms was eight months prior to treatment.
Main Results:
- Bleeding stopped immediately in seven out of eight patients post-formalin therapy.
- No further bleeding or blood transfusions were required during a four-month follow-up.
- One patient needed a repeat application after two weeks.
Conclusions:
- Endoluminal formalin is a simple, inexpensive, and effective treatment for hemorrhagic radiation proctitis.
- It provides a viable alternative for patients with severe, refractory symptoms.
- The procedure demonstrates a favorable safety profile with minimal complications.