Related Experiment Videos
Time-related effects of RU486 treatment in experimentally induced endometriosis in the rat
B Tjaden1, D Galetto, J D Woodruff
1Department of Gynecology and Obstetrics, Johns Hopkins Hospital, Baltimore, Maryland.
Objective:
To evaluate the time-dependent effect of the progesterone antagonist RU486 on experimentally induced endometriosis in the rat.
Design:
Endometriosis was induced by implanting endometrium onto the peritoneal side wall. Size of the implants was measured before and after treatment.
Participants:
Fifty-two adult female Sprague-Dawley female rats weighing 200 to 225 g.
Setting:
Departmental research laboratory of university hospital.
Intervention:
Animals treated with RU486 or vehicle only for 2, 4, 6, or 8 weeks.
Main Outcome Measures:
Size of the implant was measured before and after treatment; relative change in size of the implants was calculated.
Results:
There was not a statistically significant difference between the treatment groups and the control groups. There was no regression of endometriosis in any of the treatment groups.
Conclusions:
RU486 administered for 8 weeks in the rat model was not effective therapy for endometriosis.