Principles of surgical resection. Influence of surgical technique on treatment outcome

In the absence of curative medical therapy, surgical resection remains the cornerstone of treatment for patients with colorectal carcinoma. A thorough knowledge of colon and rectal anatomy is crucial for the formulation of an effective operative strategy. There are certain technical factors under the control of the surgeon that may have prognostic significance for the patient. These include the length of the distal margin of resection, the use of intraluminal cytotoxic solutions to reduce the viability of exfoliated cancer cells, and the technique of colon anastomosis. Curative resections should include removal of the lymphatic drainage of the tumor-bearing segment of colon. When there is adjacent organ invasion by the colonic primary, en block resection of the entire tumor mass with adequate margins is the procedure of choice. Prophylactic oophorectomy in women with colon carcinoma remains controversial. The effects of perioperative transfusion on tumor behavior remain unclear. Blood transfusions should be administered only when there is a specific medical necessity.