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Daily rhythmic variations in histamine in human blood
A Miliani1, C Catini, M Filippelli
1Fourth Division of Internal Medicine, University of Florence, Italy.
International Archives of Allergy and Immunology
|January 1, 1993
Summary
Normal subjects exhibit daily rhythmic changes in blood histamine levels, with predictable peaks and troughs. The clinical significance of these biological rhythms remains to be determined.
Area of Science:
- Chronobiology
- Human Physiology
- Immunology
Background:
- Histamine plays a crucial role in immune responses and physiological processes.
- Understanding diurnal variations in histamine is important for interpreting health data.
Purpose of the Study:
- To investigate the presence and pattern of daily rhythmic changes in blood histamine levels in healthy individuals.
- To identify the timing of peak and trough histamine concentrations throughout a 24-hour period.
Main Methods:
- Blood samples were collected from normal subjects over a 24-hour period.
- Histamine levels in blood samples were quantified.
- Statistical analysis was performed to detect rhythmic variations and determine acrophase.
Main Results:
- Daily predictable variations in blood histamine levels were observed.
- Three distinct maxima and three minima were identified within the daily cycle.
- The acrophase (time of peak) for blood histamine was determined to be at 09:13.
Conclusions:
- Healthy individuals display a circadian rhythm in blood histamine levels.
- The specific physiological or clinical significance of these observed daily histamine fluctuations is currently unknown and requires further investigation.