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Primary fibromyalgia syndrome--an outcome study
J Ledingham1, S Doherty, M Doherty
1Rheumatology Unit, City Hospital, Nottingham.
British Journal of Rheumatology
|February 1, 1993
Summary
Primary fibromyalgia syndrome (PFS) often leads to persistent symptoms and significant disability. Most patients experience ongoing pain and high levels of anxiety and depression years after diagnosis.
Area of Science:
- Rheumatology
- Clinical Medicine
- Pain Management
Background:
- Primary fibromyalgia syndrome (PFS) is a chronic condition characterized by widespread pain.
- Long-term outcomes and functional status in PFS patients require further investigation.
Purpose of the Study:
- To evaluate the long-term prognosis of patients diagnosed with primary fibromyalgia syndrome.
- To assess the persistence of symptoms, functional disability, and psychological comorbidities in PFS patients over time.
Main Methods:
- Retrospective review of 72 patients diagnosed with primary fibromyalgia syndrome.
- Assessment of symptom persistence, hyperalgesic tender sites, functional disability (Health Assessment Questionnaire, Steinbrocker index), and psychological status (Hospital Anxiety and Depression index) at a mean of 4 years post-diagnosis.
Main Results:
- 97% of patients reported persistent symptoms typical of PFS, with 60% experiencing worsening symptoms.
- 85% maintained hyperalgesic tender sites and met PFS criteria; significant functional disability was common.
- High scores on the Hospital Anxiety and Depression index were observed in 92% of patients.
Conclusions:
- Primary fibromyalgia syndrome is associated with a poor long-term prognosis, characterized by persistent symptoms and significant functional impairment.
- High prevalence of anxiety and depression comorbidities is noted in PFS patients.
- Screening investigations did not reveal the development of other diseases, refuting the idea that PFS predates other conditions.