Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Accommodating sequence changes in beta-hairpins in proteins

B L Sibanda1, J M Thornton

  • 1Crystallography Department, Birkbeck College, London, England.

Journal of Molecular Biology
|January 20, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Large-scale annotation of biochemically relevant pockets and tunnels in cognate enzyme-ligand complexes.

Journal of cheminformatics·2024
Same author

Resolvin D2 promotes host defense in a 2 - hit model of sepsis with secondary lung infection.

Prostaglandins & other lipid mediators·2022
Same author

Lipoxin A4 promotes reduction and antibiotic efficacy against Pseudomonas aeruginosa biofilm.

Prostaglandins & other lipid mediators·2020
Same author

Clinical management of Brucella suis infection in dogs and implications for public health.

Australian veterinary journal·2017
Same author

Modeling birds on wires.

Journal of theoretical biology·2016
Same author

HydroCoils, occlusion rates, and outcomes: a large single-center study.

AJNR. American journal of neuroradiology·2010
Same journal

Tesorai Search: cloud-based database search engine boosts identifications for mass spectrometry proteomics with a pretrained peptide-spectrum deep-learning model.

Journal of molecular biology·2026
Same journal

Characterization of diverse functions of NRF1 nuclear localization sequence.

Journal of molecular biology·2026
Same journal

UPF3A and UPF3B shape the transcriptome cooperatively yet oppose cell function.

Journal of molecular biology·2026
Same journal

Antibody-secreting cells integrate efficient NMD with non‑canonical UPR signaling to maintain proteostasis and support massive immunoglobulin synthesis.

Journal of molecular biology·2026
Same journal

Small molecule stabilization of diverse amyloidogenic immunoglobulin light chains revealed by hydrogen-deuterium exchange mass spectrometry.

Journal of molecular biology·2026
Same journal

UPF1 at Work: Structural and Mechanistic Insights Into a Master Regulator of Nonsense-Mediated mRNA Decay.

Journal of molecular biology·2026
See all related articles

Protein beta-hairpins accommodate sequence changes (insertions and deletions) primarily in loops. Longer insertions extend beta-ladders or form beta-bulges, aiding homologous structure modeling.

Area of Science:

  • Protein structure and bioinformatics
  • Molecular biology and biophysics

Background:

  • Beta-hairpins are crucial structural motifs in proteins.
  • Understanding how sequence variations impact protein structure is vital.

Purpose of the Study:

  • To systematically investigate how insertions and deletions (indels) are accommodated in homologous protein beta-hairpins.
  • To provide insights for modeling beta-hairpins in related protein structures.

Main Methods:

  • Analysis of 49 independent beta-hairpins across 50 protein structures from 12 protein families.
  • Classification of hairpins based on loop length and hydrogen bonding patterns.
  • Quantification of indel frequency and location within beta-hairpin structures.

Main Results:

Related Experiment Videos

  • Most indels occur in loops, with frequency decreasing sharply as indel size increases.
  • Short loops often feature glycines and readily convert between beta-turn types.
  • Longer insertions can be accommodated by extending beta-ladders or forming beta-bulges.

Conclusions:

  • Beta-hairpin structure accommodates sequence indels through various mechanisms, predominantly in loops.
  • The findings offer a framework for predicting and modeling beta-hairpin conformations in homologous proteins.