Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A rebreathing method for measuring carbon monoxide diffusing capacity. A supplement to the single-breath method

R Marshall

    The American Review of Respiratory Disease
    |March 1, 1977
    PubMed
    Summary

    A new rebreathing method accurately measures carbon monoxide diffusing capacity, even in patients with low vital capacity. This simple technique also determines functional residual capacity.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Comprehensive Observations of Magnetospheric Particle Acceleration, Sources, and Sinks (COMPASS): A Mission Concept to Explore the Extremes of Jupiter's Magnetosphere.

    Space science reviews·2026
    Same author

    Energetic Intracloud Lightning in the RELAMPAGO Field Campaign.

    Earth and space science (Hoboken, N.J.)·2021
    Same author

    Lightning Geolocation and Flash Rates From LF Radio Observations During the RELAMPAGO Field Campaign.

    Earth and space science (Hoboken, N.J.)·2021
    Same author

    Osimertinib plus platinum-pemetrexed in newly diagnosed epidermal growth factor receptor mutation-positive advanced/metastatic non-small-cell lung cancer: safety run-in results from the FLAURA2 study.

    ESMO open·2021
    Same author

    An Array of Low-Cost, High-Speed, Autonomous Electric Field Mills for Thunderstorm Research.

    Earth and space science (Hoboken, N.J.)·2020
    Same author

    Towards blood flow in the virtual human: efficient self-coupling of HemeLB.

    Interface focus·2020

    Area of Science:

    • Pulmonary Function Testing
    • Respiratory Physiology

    Background:

    • The single-breath method for measuring carbon monoxide diffusing capacity (DLCO) is standard but requires adequate patient cooperation and sufficient vital capacity.
    • Limitations in patient cooperation or small vital capacity can hinder accurate DLCO measurements using traditional methods.

    Purpose of the Study:

    • To describe and validate a novel rebreathing method for measuring carbon monoxide diffusing capacity.
    • To assess the applicability of the rebreathing method in patients unable to perform the single-breath test.
    • To evaluate the correlation between the rebreathing method and the single-breath method for DLCO measurement.

    Main Methods:

    • A rebreathing technique was developed to measure carbon monoxide diffusing capacity.
    • The same gas mixtures used in the single-breath method were employed.

    Related Experiment Videos

  • The method was tested in patients with limited vital capacity or cooperation.

    • Main Results:

    • The rebreathing method demonstrated similar results to the established single-breath method, with 80% agreement within 20% of the single-breath value.
    • The apparatus required is simple to operate.
    • The rebreathing method additionally provides a measurement of functional residual capacity (FRC).

    Conclusions:

    • The rebreathing method offers a viable alternative for DLCO measurement, particularly in challenging patient populations.
    • This method is comparable in accuracy to the single-breath technique.
    • The added benefit of FRC measurement enhances the utility of this rebreathing approach in pulmonary diagnostics.