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Expression of a common cellular phospholipase A2 by human intrauterine tissues
P Bennett1, D Slater, P Stanier
1Action Research Laboratory for the Molecular Biology of Fetal Development, Royal Post Graduate Medical School, Queen Charlotte's and Chelsea Hospital, London, England.
Prostaglandins
|February 1, 1993
Abstract:
A subclone of the three prime (3') end of a human extrapancreatic phospholipase cDNA has been generated using the polymerase chain reaction. This has been used to detect mRNA transcripts in RNA extracted from human amnion, chorion-decidua, placenta and myometrium. The carboxyl-terminus of phospholipases A2 is poorly conserved but hybridisation remained stable under conditions of high stringency. This supports the hypothesis that these tissues express a common cellular phospholipase A2 which is identical to that expressed in platelets.