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Fluoroquinolone resistance protein NorA of Staphylococcus aureus is a multidrug efflux transporter
A A Neyfakh1, C M Borsch, G W Kaatz
1Department of Medicinal Chemistry and Pharmacognosy (M/C 781), University of Illinois, Chicago 60680.
Antimicrobial Agents and Chemotherapy
|January 1, 1993
Abstract:
The gene of the Staphylococcus aureus fluoroquinolone efflux transporter protein NorA confers resistance to a number of structurally dissimilar drugs, not just to fluoroquinolones, when it is expressed in Bacillus subtilis. NorA provides B. subtilis with resistance to the same drugs and to a similar extent as the B. subtilis multidrug transporter protein Bmr does. NorA and Bmr share 44% sequence similarity. Both the NorA- and Bmr-conferred resistances can be completely reversed by reserpine.