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Related Experiment Videos

Peripseudophakic membrane. Pathologic features

M A Pavilack1, C S Foster, V O Kowal

  • 1Cornea Service, Massachusetts Eye and Ear Infirmary, Boston 02114.

Archives of Ophthalmology (Chicago, Ill. : 1960)
|February 1, 1993
PubMed
Summary

A dense fibrous membrane encased an intraocular lens, necessitating complex anterior segment reconstruction. This study identifies metaplastic lens epithelium and specific collagen types within this peripseudophakic membrane.

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Area of Science:

  • Ophthalmology
  • Histopathology
  • Biomaterials

Background:

  • Repeated penetrating keratoplasty was performed for visual rehabilitation in a 70-year-old woman.
  • A posterior chamber intraocular lens (PCIOL) was found encased in a dense fibrous membrane, obscuring the anterior and posterior chambers.

Observation:

  • The fibrous membrane extended through the optic's positioning holes, requiring careful transection for safe intraocular lens removal.
  • Anterior segment reconstruction involved membrane excision, PCIOL removal, iridoplasty, gonioplasty, anterior vitrectomy, and repeat penetrating keratoplasty.

Findings:

  • Histopathologic and ultrastructural examination revealed metaplastic lens epithelium and fibrous scar tissue within the membrane.
  • Immunofluorescence characterized the specific collagenous components of the peripseudophakic membrane, representing a novel finding.

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Implications:

  • Understanding the composition of peripseudophakic membranes is crucial for managing complex ocular conditions.
  • This research provides insights into the biological processes underlying intraocular lens encapsulation and potential therapeutic strategies.