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c-myc oncogene expression in estrogen-dependent and -independent breast cancer
R P Shiu1, P H Watson, D Dubik
1Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
Clinical Chemistry
|February 1, 1993
Abstract:
We demonstrate that c-myc gene expression is essential for growth of breast cancer cells. It also plays an important role in the progression of human breast cancer. c-myc gene amplification may be important for cancer cell invasion, but perhaps not essential for nodal metastasis. We also provide compelling evidence that the c-myc oncogene is an estrogen target gene in hormone-responsive breast cancer. Hormonal progression of breast cancer could be brought about by the enhanced expression of the c-myc gene, with gene amplification and enhanced c-myc mRNA stability being two major mechanisms involved.