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Occupational asthma induced by inhaled egg lysozyme
J A Bernstein1, A Kraut, D I Bernstein
1College of Medicine, University of Cincinnati.
Chest
|February 1, 1993
Summary
Occupational asthma was diagnosed in a pharmaceutical worker exposed to egg lysozyme powder. This case highlights the risk of developing specific IgE-mediated hypersensitivity to lysozyme from inhalation exposure.
Area of Science:
- Occupational Medicine
- Allergy and Immunology
- Pulmonology
Background:
- A pharmaceutical industry worker manufacturing egg white-derived lysozyme developed respiratory symptoms.
- The production involved large quantities of purified dried lysozyme powder weekly.
Observation:
- The worker experienced immediate-onset asthma symptoms after two months of exposure.
- Skin prick tests were positive for egg lysozyme, and serum specific IgE was detected.
- Lung function tests showed decrements in peak expiratory flow rates correlating with exposure.
Findings:
- A positive bronchoprovocation challenge confirmed an isolated immediate asthmatic response to lysozyme powder.
- This represents the first documented case of lysozyme-induced asthma due to occupational inhalation exposure to egg lysozyme.
Implications:
- Egg lysozyme is a potential occupational allergen, necessitating workplace safety measures.
- Early diagnosis and avoidance are crucial for managing lysozyme-induced occupational asthma.
- Further research into the allergenic potential of lysozyme in industrial settings is warranted.