[Histogenesis and morphological characteristics of stomach cancer]

Histological and histochemical studies of stomach cancer and comparisons of characteristics of highly differentiated adenocarcinoma (24 observations) and nondifferentiated cancer (51 observations) revealed no differences in the character of the secret and in the activity of alkaline phosphatase in tumoral cells of glandular and nondifferentiated cancer. At the same time different localization of primary cancer was established: nondifferentiated cancer--in the region of glandular necks and basal parts of the mucosa, adenocarcinomas--in the surface regions. Comparison of the data obtained with features of physiological regeneration of the epithelium of the gastric mucosa justifies the assumption that foveate epithelium of nondifferentiated cancer, epithelium of the glandular neck, was the source of origination of adenocarcinoma. A different histogenesis of adenocarcinoma and nondifferentiated cancer accounts for their morphological differences and characteristics of the clinical course.