Related Experiment Video
Updated: Aug 9, 2026

Multiplex Cytokine Profiling of Stimulated Mouse Splenocytes Using a Cytometric Bead-based Immunoassay Platform
Published on: November 9, 2017
How cytokines signal messages within cells
1Rockefeller University, Laboratory of Signal Transduction, New York, NY 10012.
Abstract:
The intracellular signaling pathways used by cytokines to modulate the activity of immune effector cells have been the focus of intensive research. Cytokines interact with specific receptors on the plasma membrane, and this information is transduced into internal signals, often involving a cascade of kinases. These signals activate substrate proteins that serve as effectors within the cell. A number of protein kinase C substrates have been characterized. The function of one of these substrates, known as MARCKS (myristoylated alanine-rich C kinase substrate), appears to be important to the control of macrophage and neutrophil motility and may partially explain the modes of action of tumor necrosis factor and interleukin-8.
More Related Videos
Related Concept Videos
What is Cell Signaling?
What is Cell Signaling?
Overview of Cell Signaling
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Types of Signaling Molecules
The JAK-STAT Signaling Pathway
Overview of Cell Signaling
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...

