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[The influence of normovolemic hemodilution on myocardial blood flow]
M Kobori1, H Negishi, A Hosoyamada
1Department of Anesthesiology, School of Medicine, Showa University, Tokyo.
Normovolemic hemodilution was carried out in adult mongrel dogs by using SALIN-HES, and myocardial blood flow was measured by hydrogen clearance method. Moreover, distribution of the blood flow against cardiac output was calculated. The hematocrit levels before hemodilution was 40%. The hematocrit level by hemodilution (at 4 stages) were 26% at S1, 19% at S2, 9% at S3 and 5% at S4. Total of 4 localized myocardial blood flows in the outer and inner layer areas in both left and right cardiac ventricles were measured. All myocardial blood flows from S1 to S4 were significantly elevated by hemodilution and particularly the maximum level was observed at S3. The increase of the myocardial blood flow by hemodilution was larger in the left ventricle area than that in the right ventricle area. The distribution of the blood flow against cardiac output in the left ventricle area was elevated at S1 and S2, while no significant change was observed at S3 and S4. No significant change in the right ventricle area was observed from S1 to S4. The higher the degree of hemodilution, the higher was the decrease of blood flow ratio of the inner layer area/outer layer area in the left ventricle, but no change was observed in the right ventricle area.
Normovolemic hemodilution was carried out in adult mongrel dogs by using SALIN-HES, and myocardial blood flow was measured by hydrogen clearance method. Moreover, distribution of the blood flow against cardiac output was calculated. The hematocrit levels before hemodilution was 40%. The hematocrit level by hemodilution (at 4 stages) were 26% at S1, 19% at S2, 9% at S3 and 5% at S4. Total of 4 localized myocardial blood flows in the outer and inner layer areas in both left and right cardiac ventricles were measured. All myocardial blood flows from S1 to S4 were significantly elevated by hemodilution and particularly the maximum level was observed at S3. The increase of the myocardial blood flow by hemodilution was larger in the left ventricle area than that in the right ventricle area. The distribution of the blood flow against cardiac output in the left ventricle area was elevated at S1 and S2, while no significant change was observed at S3 and S4. No significant change in the right ventricle area was observed from S1 to S4. The higher the degree of hemodilution, the higher was the decrease of blood flow ratio of the inner layer area/outer layer area in the left ventricle, but no change was observed in the right ventricle area.