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[Continuous infusion of heparin in newborn infants with disseminated intravascular coagulation]
Boletin Medico Del Hospital Infantil De Mexico
|March 1, 1977
Insights
Heparin therapy effectively treated disseminated intravascular coagulation (DIC) in infants. Nine out of ten infants recovered quickly with normalized lab tests indicating successful treatment.
Area of Science:
- Pediatric Hematology
- Neonatal Critical Care
- Coagulation Disorders
Context:
- Disseminated intravascular coagulation (DIC) is a life-threatening condition in infants.
- Effective treatment strategies for neonatal DIC are crucial.
- Heparin is an anticoagulant with potential therapeutic applications in DIC.
Purpose:
- To evaluate the efficacy of continuous heparin perfusion in treating infants with DIC.
- To assess clinical and laboratory outcomes in infants receiving heparin for DIC.
Summary:
- Ten infants diagnosed with DIC received continuous heparin perfusion at 100 U/kg/day.
- Nine out of ten infants showed successful therapeutic results.
- Recovery was evidenced by clinical improvement, normalization of hemostatic and fibrinogen tests, and negative paracoagulation tests.
Impact:
- Demonstrates the potential of heparin as a safe and effective treatment for neonatal DIC.
- Provides evidence for improved clinical management and patient outcomes in pediatric coagulation disorders.
- Highlights the importance of early and appropriate anticoagulant therapy in critical neonatal conditions.
Abstract:
This study was carried out in ten infants with DIC who were given heparin at the rate of 100 U. per kilogram of body weight and per day in continuous perfusion. Successful therapeutic results were achieved in nine cases made evident by recovery and quick clinical control of their DIC condition, shown by normalization of hemostatic and fibrinogen tests and negative paracoagulation tests.