Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Liposomes. A perspective for dermatologists

M J Hope1, C N Kitson

  • 1Division of Dermatology, University of British Columbia, Vancouver, Canada.

Dermatologic Clinics
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Production of large unilamellar vesicles by a rapid extrusion procedure: characterization of size distribution, trapped volume and ability to maintain a membrane potential.

Biochimica et biophysica acta·2012
Same author

Disability can be avoided after open fractures in Africa-results from Malawi.

Injury·2004
Same author

Acute compartment syndrome in the absence of fracture.

Journal of orthopaedic trauma·2004
Same author

Characterization of the inhibitory effect of PEG-lipid conjugates on the intracellular delivery of plasmid and antisense DNA mediated by cationic lipid liposomes.

Biochimica et biophysica acta·2001
Same author

Immune stimulation by a CpG-containing oligodeoxynucleotide is enhanced when encapsulated and delivered in lipid particles.

The Journal of pharmacology and experimental therapeutics·2001
Same author

Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: formation of novel small multilamellar vesicle structures.

Biochimica et biophysica acta·2001
Same journal

The Evidence Is In: Devices and Biologics Reshaping Modern Dermatology.

Dermatologic clinics·2026
Same journal

Energy-Based Devices for Body Contouring.

Dermatologic clinics·2026
Same journal

Microfocused Ultrasound with Visualization for Skin Tightening: Clinical Applications, Safety, and Technical Considerations.

Dermatologic clinics·2026
Same journal

Devices in Onychomycosis: A Status Update.

Dermatologic clinics·2026
Same journal

Acne Laser Devices in Dermatology.

Dermatologic clinics·2026
Same journal

Fractional Laser Therapy for Androgenetic Alopecia: Mechanisms, Clinical Evidence, and Practical Implementation.

Dermatologic clinics·2026
See all related articles

Intact liposomes likely do not penetrate the skin barrier for drug delivery. However, liposomes can alter how chemicals distribute on the skin, offering potential for topical therapies.

Area of Science:

  • Dermatology
  • Pharmaceutics
  • Biophysics

Background:

  • Liposomes are widely investigated for topical drug delivery.
  • The stratum corneum presents a significant barrier to transdermal penetration.

Purpose of the Study:

  • To evaluate the potential of intact liposomes to act as carriers across the skin barrier.
  • To explore the influence of liposomes on the biodistribution and activity of applied chemicals on the skin.

Main Methods:

  • In silico modeling of liposome-skin interactions.
  • In vitro skin penetration studies.
  • Analysis of chemical and lipid penetration.

Main Results:

  • Intact liposomes are unlikely to traverse the stratum corneum intact.

Related Experiment Videos

  • Liposomes can modify the cutaneous biodistribution of applied chemicals, affecting their activity.
  • Liposomal lipids demonstrate penetration of the skin barrier, with varied effects.

    • Conclusions:

    • Liposomes may not function as direct carriers through the stratum corneum.
    • Liposomes' ability to modify chemical biodistribution and the penetration of liposomal lipids present significant potential for topical therapeutic applications.