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Calbistrins, novel antifungal agents produced by Penicillium restrictum. II. Isolation and elucidation of structure
G M Brill1, R H Chen, R R Rasmussen
1Anti-infective Research, Abbott Laboratories, Abbott Park, IL 60064.
The Journal of Antibiotics
|January 1, 1993
Abstract:
The novel antifungal agents, calbistrins A, B, C and D have been isolated from a strain of Penicillium restrictum (AB 1875C-28). The four congeners were separated by bioactivity directed fractionation using countercurrent chromatography and preparative-HPLC. NMR studies revealed that the calbistrins each contain a carboxylic acid conjugated tetraene attached through an aliphatic ester linkage to a hexahydronaphthalene system.