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Segmental hyperhidrosis in syringomyelia with Chiari malformation

K Sudou¹, K Tashiro

¹Department of Neurology, Hokkaido University School of Medicine, Sapporo, Japan.

Journal of Neurology

|February 1, 1993

Summary

Segmental hyperhidrosis, a rare sweating disorder, was observed in three patients with syringomyelia and Chiari malformation. This condition correlated with sensory disturbances, suggesting a link between neurological conditions and sweating patterns.

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Area of Science:

Neurology
Neurosurgery
Dermatology

Background:

Syringomyelia and Chiari malformation are complex neurological conditions affecting the spinal cord and brainstem.
Hyperhidrosis, or excessive sweating, can manifest in various patterns, impacting quality of life.

Observation:

Three cases of syringomyelia with Chiari malformation were identified.
Segmental hyperhidrosis was a notable clinical presentation in all affected individuals.
The iodine-starch test confirmed hyperhidrosis in specific dermatomes.

Findings:

Hyperhidrosis areas corresponded closely to regions of sensory deficits.
Magnetic resonance imaging (MRI) confirmed the diagnosis of syringomyelia and Chiari malformation.
The study explored two potential pathophysiological mechanisms: preganglionic neuron stimulation and disruption of inhibitory pathways.

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Implications:

This research highlights a potential association between syringomyelia/Chiari malformation and segmental hyperhidrosis.
Understanding the pathogenesis may lead to targeted treatments for hyperhidrosis in these patients.
Further investigation is warranted to elucidate the precise neurological pathways involved.