Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vascularized tail bone grafts in rats

T Sempuku1, S Tamai, S Mizumoto

  • 1Department of Orthopaedic Surgery, Nara Medical University, Japan.

Plastic and Reconstructive Surgery
|March 1, 1993
PubMed
Summary

This study developed a new vascularized bone graft model using rat tails. Vascularized grafts demonstrated successful bone formation and adaptation when transferred to femurs, unlike non-vascularized grafts.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Double-blind and single-blind retractable placebo needles.

Anaesthesia·2018
Same author

Inhibitory Effect of the Conformation of Amylose as a Function of I2 Concentration on Glucoamylase Activity.

Bioscience, biotechnology, and biochemistry·2016
Same author

Risk factors for dislocation of the ulnar nerve after simple decompression for cubital tunnel syndrome.

Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand·2014
Same author

Long-term follow-up of periarterial sympathectomy for chronic digital ischaemia.

The Journal of hand surgery, European volume·2012
Same author

Changes in blood circulation of the contralateral Achilles tendon during and after acupuncture and heating.

International journal of sports medicine·2011
Same author

Optoelectronic fuzzy inference system based on beam-scanning architecture.

Applied optics·2010

Area of Science:

  • Orthopedic Surgery
  • Regenerative Medicine
  • Vascular Biology

Background:

  • Vascularized bone grafts are crucial for long-bone defect repair.
  • Establishing reliable experimental models is essential for studying graft integration.
  • Previous models have limitations in mimicking natural bone healing processes.

Purpose of the Study:

  • To establish and evaluate a novel experimental model for vascularized corticocancellous bone grafts using rat tails.
  • To assess the viability and morphologic adaptation of vascularized tail bone grafts transferred to the femur.
  • To compare the healing response of vascularized versus non-vascularized bone grafts.

Main Methods:

  • Vascular anatomy of the rat tail was investigated.
  • Vascularized tail bone grafts were created and transferred to resected femur defects in rats.

Related Experiment Videos

  • Graft viability and bone formation were monitored over 16 weeks.
  • Histological analysis examined bone resorption and formation.

    • Main Results:

    • Vascularized grafts exhibited significant reactive periosteal bone formation within the first two weeks.
    • Sustained active bone formation was observed in vascularized grafts throughout the 16-week period.
    • While both resorption and formation occurred in cancellous bone, vascularized grafts showed better integration and adaptation compared to non-vascularized grafts exhibiting creeping substitution.

    Conclusions:

    • The developed rat tail model is viable for studying vascularized corticocancellous bone grafts.
    • Vascularized bone grafts undergo successful morphologic adaptation and integration in long-bone defects.
    • This model provides a foundation for further research into enhancing bone graft success through vascularization.