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Amyloid stroma in meningiomas
M P Foschini1, T D'Adda, C Bordi
1Department of Pathology, University of Bologna, Italy.
Virchows Archiv. A, Pathological Anatomy and Histopathology
|January 1, 1993
Abstract:
Twenty-three cases of meningiomas with psammoma bodies (PBs) and 15 without PBs have been studied using histochemical, ultrastructural and immunohistochemical methods for amyloid. Amyloid was found in all cases showing PBs and in only 5 cases in the group devoid of PBs. Meningiomas may contain amyloid in their stroma.
Insights
Meningiomas with psammoma bodies (PBs) frequently contain amyloid. This study found amyloid in all PB-positive meningiomas, suggesting a link between these features in brain tumors.
Area of Science:
- Neuropathology
- Oncology
- Biochemistry
Background:
- Meningiomas are the most common primary tumors of the central nervous system.
- Psammoma bodies (PBs) are calcified structures found in some meningiomas.
- The presence and significance of amyloid in meningiomas are not fully understood.
Purpose of the Study:
- To investigate the presence of amyloid in meningiomas.
- To determine the association between psammoma bodies and amyloid deposition in meningiomas.
Main Methods:
- Histochemical staining for amyloid.
- Ultrastructural analysis.
- Immunohistochemical methods for amyloid detection.
- Comparative analysis of meningiomas with and without psammoma bodies.
Main Results:
- Amyloid was detected in all 23 meningiomas exhibiting psammoma bodies.
- Amyloid was found in only 5 out of 15 meningiomas lacking psammoma bodies.
- These findings indicate a strong correlation between psammoma bodies and amyloid presence.
Conclusions:
- Meningiomas, particularly those with psammoma bodies, frequently contain amyloid.
- Amyloid deposition may be a common stromal component in certain meningioma subtypes.
- Further research is warranted to elucidate the role of amyloid in meningioma pathogenesis.