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Amyloid stroma in meningiomas

M P Foschini1, T D'Adda, C Bordi

  • 1Department of Pathology, University of Bologna, Italy.

Virchows Archiv. A, Pathological Anatomy and Histopathology
|January 1, 1993
PubMed
Summary

Meningiomas with psammoma bodies (PBs) frequently contain amyloid. This study found amyloid in all PB-positive meningiomas, suggesting a link between these features in brain tumors.

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Area of Science:

  • Neuropathology
  • Oncology
  • Biochemistry

Background:

  • Meningiomas are the most common primary tumors of the central nervous system.
  • Psammoma bodies (PBs) are calcified structures found in some meningiomas.
  • The presence and significance of amyloid in meningiomas are not fully understood.

Purpose of the Study:

  • To investigate the presence of amyloid in meningiomas.
  • To determine the association between psammoma bodies and amyloid deposition in meningiomas.

Main Methods:

  • Histochemical staining for amyloid.
  • Ultrastructural analysis.
  • Immunohistochemical methods for amyloid detection.
  • Comparative analysis of meningiomas with and without psammoma bodies.

Main Results:

  • Amyloid was detected in all 23 meningiomas exhibiting psammoma bodies.
  • Amyloid was found in only 5 out of 15 meningiomas lacking psammoma bodies.
  • These findings indicate a strong correlation between psammoma bodies and amyloid presence.

Conclusions:

  • Meningiomas, particularly those with psammoma bodies, frequently contain amyloid.
  • Amyloid deposition may be a common stromal component in certain meningioma subtypes.
  • Further research is warranted to elucidate the role of amyloid in meningioma pathogenesis.

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