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The association of age with gastric emptying
N Gainsborough1, V L Maskrey, M L Nelson
1Department of Health Care of the Elderly, King's College School of Medicine and Dentistry, Denmark Hill, London.
Age and Ageing
|January 1, 1993
Abstract:
Gastric emptying is important as a rate-limiting step in the absorption of orally administered drugs. Paracetamol absorption kinetics were used to compare gastric emptying in 19 fit elderly and 19 fit young volunteers. The results showed no significant difference in any of the derived parameters (t1/2abs, tlag and tmax) between the two groups. These results suggest that ageing does not impair this rate-limiting step in drug absorption.