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Secondary syphilis and the nephrotic syndrome
W Hunte1, F al-Ghraoui, R J Cohen
1Cleveland Clinic Foundation, Ft. Lauderdale, FL.
Journal of the American Society of Nephrology : JASN
|January 1, 1993
Summary
Nephrotic syndrome can be caused by secondary syphilis, a sexually transmitted infection. This case highlights the importance of considering syphilis in patients with kidney disease and other health issues like diabetes.
Area of Science:
- Nephrology
- Infectious Diseases
- Pathology
Background:
- Nephrotic syndrome is a complex kidney disorder often associated with various underlying conditions.
- Secondary syphilis, a sexually transmitted infection, can present with diverse clinical manifestations.
- Diabetes mellitus is a common comorbidity that can affect renal function.
Observation:
- A case study of a 21-year-old Black man presenting with nephrotic syndrome.
- The patient had a history of secondary syphilis and diabetes mellitus.
- Renal biopsy revealed stage I membranous glomerulopathy with mesangial hyperplasia and deposits.
Findings:
- Histological findings were consistent with syphilitic nephropathy.
- The clinical presentation and biopsy results underscore a link between syphilis and kidney damage.
- This case demonstrates an uncommon but significant renal manifestation of secondary syphilis.
Implications:
- Highlights the critical need for internists and nephrologists to consider sexually transmitted diseases, including syphilis, as potential causes of renal disease.
- Emphasizes that infections like syphilis and hepatitis B, alongside HIV, can lead to substantial kidney problems.
- Suggests broader screening for infectious etiologies in patients presenting with unexplained nephrotic syndrome.