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Related Experiment Videos

How common is increased airway reactivity amongst the elderly?

J R Horsley1, I J Sterling, W E Waters

  • 1Department of Geriatric, University of Southampton, UK.

Gerontology
|January 1, 1993
PubMed
Summary

Bronchial hyperreactivity is common in the elderly, with low forced expiratory volume in 1 second (FEV1) predicting increased airway reactivity. Early detection of low FEV1 may reduce respiratory illness in older adults.

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Area of Science:

  • Pulmonology
  • Geriatric Medicine
  • Respiratory Medicine

Background:

  • Bronchial hyperreactivity is a hallmark of asthma.
  • Prevalence in the elderly population is not well-established.

Purpose of the Study:

  • To investigate the prevalence of bronchial hyperreactivity in an elderly cohort.
  • To explore the relationship between baseline lung function and bronchial hyperreactivity.

Main Methods:

  • Recruited elderly subjects (over 65) responding to a respiratory symptom questionnaire.
  • Conducted spirometry and methacholine bronchial challenge testing.
  • Determined the provocative dose of methacholine causing a 20% fall in FEV1 (PD20).

Main Results:

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  • 43% of subjects exhibited bronchial hyperreactivity (PD20 < 6.13 µmol).
  • 12% had highly reactive airways (PD20 < 1.0 µmol).
  • Low baseline FEV1 (1-1.5 L) was significantly associated with increased bronchial hyperreactivity (p < 0.01).

    • Conclusions:

    • Bronchial hyperreactivity is more prevalent in the elderly than previously thought.
    • Low baseline FEV1 is a predictor of increased airway reactivity in older adults.
    • Early identification of individuals with low FEV1 may aid in reducing respiratory morbidity.