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Psoriasis-like lesions in guinea pigs receiving propranolol
1University of Istanbul, Experimental Medicine Research and Application Center (DETAM), Turkey.
International Journal of Dermatology
|February 1, 1993
Summary
Systemic propranolol, a beta-blocker, induced psoriasiform skin lesions in guinea pigs. Topical application did not cause similar effects, suggesting systemic administration is key for this adverse skin reaction.
Area of Science:
- Dermatology
- Pharmacology
- Toxicology
Background:
- Beta-blockers are known to induce psoriasiform eruptions.
- Systemic propranolol's specific dermatological effects require formal investigation.
Purpose of the Study:
- To investigate the skin effects of systemic propranolol administration.
- To determine if propranolol can induce psoriasiform lesions.
Main Methods:
- Systemic administration of propranolol (0.1 mg/day) via gavage to guinea pigs.
- Control group received normal saline.
- Histopathological examination of skin biopsies.
Main Results:
- Propranolol induced psoriasiform lesions in 71% of guinea pigs after 30 days.
- Histopathology revealed acanthosis, parakeratosis, microabscesses, and dermal inflammation.
- Topical propranolol did not induce clinical psoriasiform changes but caused acanthosis and papillomatosis.
Conclusions:
- Systemic propranolol can induce psoriasiform skin eruptions in a preclinical model.
- The findings highlight a potential adverse effect of systemic beta-blocker use.
- Further research into the mechanism of propranolol-induced skin lesions is warranted.