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Related Experiment Videos

Coccidioidomycosis and pregnancy

C M Peterson1, K Schuppert, P C Kelly

  • 1Department of Medicine, Maricopa Medical Center, Phoenix, Arizona.

Obstetrical & Gynecological Survey
|March 1, 1993
PubMed
Summary

Pregnant women with respiratory symptoms require coccidioidomycosis evaluation. Early diagnosis and treatment with amphotericin B reduce high maternal and neonatal mortality risks.

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Area of Science:

  • Medical Mycology
  • Maternal-Fetal Medicine
  • Infectious Diseases

Background:

  • Coccidioidomycosis poses risks during pregnancy, particularly for dissemination.
  • Respiratory symptoms like pleuritic pain and cough warrant investigation.

Observation:

  • Evaluation includes travel history, endemic area residency, and skin manifestations (erythema).
  • Diagnostic methods include sputum culture, wet mount, and serological tests.
  • Dissemination risk is highest in the second and third trimesters, assessed by complement-fixation titer.

Findings:

  • Aggressive amphotericin B treatment improves outcomes in disseminated cases.
  • Transplacental spread is not indicated by current case reports.
  • Reactivation can occur in pregnant patients with prior disseminated disease, especially insulin-dependent diabetics.

Implications:

  • Prompt diagnosis and management are crucial for pregnant women with suspected coccidioidomycosis.
  • Understanding dissemination risks and treatment efficacy is vital for maternal and neonatal health.
  • Awareness of reactivation potential in specific patient groups aids clinical management.

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