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Updated: Aug 19, 2026

A Pre-Clinical Porcine Model of Orthotopic Heart Transplantation
Published on: April 27, 2019
Risk/benefit ratio of perioperative OKT3 in cardiac transplantation
M R Johnson1, G M Mullen, E J O'Sullivan
1Department of Medicine, Loyola University Medical Center, Maywood, Illinois 60153.
Abstract:
This study shows that perioperative OKT3 provides no benefit in terms of the time of onset or frequency of rejection or patient survival. However, it does result in an increased incidence of infection, particularly CMV infection. Thus, the risk/benefit ratio of perioperative OKT3 does not appear favorable. However, a multicenter, randomized trial including a larger number of patients and longer patient follow-up will be required to definitively answer the question.
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