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Updated: Jul 31, 2026

Induction and Assessment of Class Switch Recombination in Purified Murine B Cells
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Induction and Assessment of Class Switch Recombination in Purified Murine B Cells

Published on: August 14, 2010

Towards a comprehensive view of immunoglobulin class switching

C M Snapper, J J Mond

    Immunology Today
    |January 1, 1993
    PubMed

    While it is well established that T cells play a prominent role in regulating Ig isotype switching in response to T-cell-dependent (TD) antigens, the events which control this process in response to antigens that do not recruit antigen-specific T cells (T-cell-independent (TI) antigens) is less clear. In this article, Clifford Snapper and James Mond suggest that the nature of the B-cell activator, in combination with cytokines produced by antigen non-specific cells, including macrophages, NK cells, and polyclonally activated B cells, may play an important role in the process leading to Ig isotype switching in response to TI antigens.

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